Fat10 in cancer

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August undefined, 2024

WebNov 24, 2014 · FAT10 (HLA-F-adjacent transcript 10) is a ubiquitin-like modifier that is commonly overexpressed in various tumors. It was found to play a role in mitotic regulation through its interaction with mitotic arrest … WebJun 29, 2015 · Our previous study revealed that FAT10 expression is induced by TNF-α through the NF-κB pathway in cancer cells (including HCT116 and HepG2) making them resistant to TNF-α-induced apoptosis and facilitating CIN (Ren et al., 2011). Silibinin is a flavonoid isolated from milk thistle seeds with anti-cancer effects against a variety of …

Disruption of FAT10–MAD2 binding inhibits tumor …

WebThe ubiquitin-like modifier FAT10 decorates autophagy targeted Salmonella and contributes to resistance of mice. Journal of Cell Science. 15; 127 (22): 4883-93, 2014. WebSep 14, 2014 · The FAT10 gene is overexpressed in various cancers, such as gastrointestinal cancer, HCC, pancreatic ductal adenocarcinoma, and human glioma . In the liver, FAT10 overexpression is an epigenetic marker for liver neoplasia ( 13 ). road conditions from sacramento to reno

Frontiers FAT10 is a Prognostic Biomarker and Correlated With …

WebIn this study, we did a bioassay employing mice with a dominant-negative p53 mutation (p53(Val135/WT)) to assess whether a germ-line p53 mutation predisposed mice toward the development of squamous c WebNov 1, 2024 · Since these special mechanisms regulated by FAT10 are involved in many significant cellular pathways promoting the progression of cancer, emerging evidence … WebAug 30, 2024 · To evaluate the expression of FAT10 among various digestive system tumors, FAT10 expression was first evaluated in digestive cancer samples. Based on an array containing 4 digestive cancer samples from patients and corresponding noncancerous tissues for immunohistochemical staining, it was found that FAT10 expression was up … snapdeal shipping policy

The sequence of human FAT10 gene. (A) The human FAT10

The ubiquitin-like modifier FAT10 in cancer development

WebMay 25, 2024 · To evaluate the expression of FAT10 among various digestive system tumors, FAT10 expression was first evaluated in digestive cancer samples. Based on an … WebThe results of our FAT10 survival analysis for cancer types of interest show that FAT10 expression was increased in SKCM and correlated with a better survival rate in … road conditions going to lake tahoeWebNational Center for Biotechnology Information road conditions google maps

"WebFAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream targets such as MAD2, p53 or β-catenin, leading to enhanced survival, proliferation, invasion and metastasis formation of cancer cells but also of non-malignant cells. " - Fat10 in cancer

Fat10 in cancer

p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1 …

WebJun 10, 2024 · Importantly, FAT10 is commonly overexpressed in numerous types of cancer [9,10]. In previous studies, FAT10, when expressed in high levels, has been shown to result in increased mitotic non-disjunction and chromosome instability, leading to … WebApr 1, 2024 · In addition, FAT10 may be a novel cancer biomarker that contributes to proliferation, invasion, and metastasis in a broad spectrum of cancer cells, including hepatocellular carcinoma (HCC), glioma, and gastric carcinoma. These findings imply that FAT10 will be a candidate target during treatment of cardiovascular conditions due to its ...

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WebFAT10 is involved in cancer development, however, its biological role is still unclear, as well as its biochemical and cellular regulation. To identify pathways underlying FAT10 expression in the context of pro-inflammatory stimulation, which characterizes the cancerous environment, we implemented a phenotypic transcriptional reporter screen ... WebFAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream …

WebNov 9, 2012 · Biochemical and biophysical research communications (ISSN: 0006-291X, 1090-2104) WebJan 15, 2024 · Aim: To examine FAT10 expression and to analyze the relationship between FAT10 expression and the clinicopathological parameters of CRC. Methods: FAT10 expression in 61 cases of CRC and para-cancer colorectal tissues was measured by immunohistochemistry and Western blotting. The relationship between FAT10 …

WebMar 29, 2024 · FAT10 promotes chemotherapeutic resistance in pancreatic cancer by inducing epithelial-mesenchymal transition via stabilization of FOXM1 expression. Parkin … WebAn overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest ...

WebThe FAT10 protein has previously been revealed to be expressed in a number of breast and gastrointestinal tumor tissues . The expression levels of FAT10 and PCNA in cervical cancer tissue samples and surrounding tumor tissue samples obtained from human patients were investigated via IHC analysis using anti-FAT10 and anti-PCNA antibodies.

WebAug 14, 2016 · To further investigate whether FAT10 regulates eEF1A1 expression in other cancer cells, we first examined the levels of FAT10 and eEF1A1 by Western blot analysis in a variety of cancer cell lines (i.e., HCC, breast cancer, colorectal cancer, pancreatic cancer, and cervical cancer). road conditions glenwood springs coWebConclusion: UBD upregulation was linked to better clinical prognosis, favorable pathological features, and good treatment response in rectal cancer patients undergoing CCRT. These results suggest UBD is a biomarker for rectal cancer. Keywords: ubiquitin D, UBD, FAT10, rectal cancer, concurrent chemoradiotherapy. road conditions from spokane to yakimaWebFAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer Feng Xue,1,2,* Lin Zhu,3,* Qing-wei Meng,1 Liyan Wang,2 Xue-song Chen,1 Yan-bin Zhao,1 Ying Xing,1 Xiao-yun Wang,1 Li Cai1 1The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, 2Department of Medical Oncology, … snapdeal share price todayWebNov 13, 2024 · As FAT10 overexpression has significant pro-malignant properties in different cancer types, and FAT10 affects substrate proteins and results in bio-functional … snapdeal tracking my orderWebUbiquitin D Rabbit Monoclonal Antibody. FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for ... snapdeal woodland rain jacket price 1000WebJul 14, 2024 · PurposeUbiquitin D (UBD) is a member of the ubiquitin-like modifier (UBL) family and is highly expressed in a variety of cancers including colorectal cancer (CRC). However, the mechanisms of its regulatory roles in CRC are largely elusive. In this study, we revealed the effect of UBD on the proliferation of CRC.MethodsThe expression of UBD in … snapdeal seller support contact numberWebDiabetes is a global health problem with more than 550 million people predicted to be diabetic by 2030. A major complication of diabetes is cardiovasc… road conditions grapevine california